Why is it called Peyronie's Disease?

Is Peyronie's really a disease or is it more a condition or syndrome?It really bugs me that Peyronie's is called a disease.  It is not caused by a Virus or Bacteria, it is not Cancer, it is not really a disease at all.  So why is it labeled as a disease?  When we think of STD's (sexually transmitted disease) there is a stigma that accompanies these conditions. Peyronie's is not communicable or contagious, you can't give it to someone else. 

So what is Peyronie's?  Well, if you are suffering from this affliction, you know it causes deformity, it is painful, it damages your self esteem and image as a man.  There is the fear factor that accompanies this syndrome, which is often followed by detachment and anger.  I remember asking myself, "Why Me?" and thinking, "This isn't fair!"  When my doctor and urologist told me I had a disease, it hit me hard.  I was devastated!  When they told me the gold standard of treatment was surgery, and that I was a good candidate, I fell into depression and was inconsolable.  It was at this point that I decided to do something pro-active.  Let's take a look now at what this syndrome really is.

  • Scar tissue, Skin changes, & Lumps: This is what really generates fear. Men often think they are developing cancer.  This condition is actually caused by a build up of plaque at the site of micro injuries.  Over time this plaque hardens into scar tissue and can form a lump or deformity which adheres to the sheath (Tunica Albugenia) that houses the erectile tissue (Corpus Cavernosum). If left untreated, the plaque will calcify and become a hard lump, feeling like a pea sized bump or tumor under the skin.
  • Pain: Pain is most often experienced, when you are getting an erection.  Some men experience continuous pain.  This is a result of the scar tissue that is not pliable, like the rest of the penis, adhering to the normal tissue of the penis.  During the process of erection the nerves are letting you know that something is wrong by signaling pain. Although rare, the plaque can adhere to nerves, that will cause constant pain.
  • Curvature/Bending: This is the embarrassing part of Peyronie's and it can really inhibit satisfying sexual intercourse. Think of one of those long balloons that entertainers twist and tie into all kinds of shapes for children at fairs and festivals.  If you think of your penis as one of those balloons it makes it easy to imagine how this bending occurs.  The balloon is straight or may have some natural curve, but it is normal.  Now take a piece of duct tape and put it on one side of the balloon.  When it is blown up the balloon will curve around the tape that adheres to it's side, causing a bend.  That is what the scar tissue is doing to your penis.  The scar is not pliable (like the duct tape) but the penis is pliable (like the balloon) so the penis bends around the scar.
  • Erectile Dysfunction (ED):  Partial or complete erectile dysfunction sometimes accompanies Peyronie's.  This can be psychological or physiological. The mind is a big part of sex, and embarrassment and perception can often cause ED. There is also the physical aspect of the plaque becoming so large that it causes ED by invading the erectile tissue and blocking circulation to the penis after the plaque.
 All of this is definitely an affliction & a syndrome but it isn't a "disease".  So I want to set you mind at ease.  You didn't do anything to be ashamed or embarrassed of.  The cause at this point is beyond your control.  It is important to accept what you cannot change and not to wrestle with misplaced guilt.  Don't hold on to anger and resentment, but be proactive in your treatment.  Seek help and support from your Loved ones, and develop a plan of action.  This condition will not go away by itself.  Ignoring the problem or pretending like it does not exist, is the worst course of inaction. Remember with Peyronie's, time without treatment is your enemy.  The best time to take action, and prevent surgery is in the earlier acute stages, when the plaque/scar has not calcified.

Penis Injections for Erectile Dysfunction

This video is very informative, but there is a disturbing message, about one of the leading new causes of Peyronie's Disease.
Injections for erectile dysfunction

I have heard a lot of advertisements about the treatment of erectile dysfunction on the radio recently.  This treatment method involves injection of a drug,  Alprostadil. One of the warnings is; do not receive injections if you have abnormal curvature or genetic penis defects. 

Alprostadil injections are self administered and effective in giving erections in over 80% of men.  Self administering an injection though, could be considered risky.  Men are given instructions by their doctor or nurse on how to inject themselves.  There is also a suppository form of the drug that is less effective, but also a drastically reduces risk of damage to the penis.

Penile Injection Therapy The first injection should be administered by the doctor in his office.  The following injections will be done by the patient in his home.  The problem I see with this method, is a man has to inject himself every time he is going to have intercourse.  The chances for injury and internal damage could be cumulative, and increase over time.

Injection therapy for erectile dysfunction is resorted to after oral treatment has failed, (Sildenafil, Viagra, Cialis, Levitra) or, due to preexisting medical conditions, a patient cannot take PDE5 inhibitor meds.

Low Testosterone and Peyronie's

Low Testosterone Causes and Natural Cures:
There is a high incidence of men with Peyronie's Disease, that also having low testosterone. This is not surprising, when you consider that low testosterone levels are linked to slower healing in the body.  Testosterone is the male hormone that defines masculinity.  It is what makes us men.  Some of the symptoms of Low T are:

  • Decrease in energy
    That old broken run-down feeling
  • Loss of stamina
  • Low libido
  • General irritability
  • Lack of concentration
  • Decrease in muscle tone
  • Increase in body fat, even with reduced caloric intake. 
The worst part about low T, is if you don't do something proactive to change things, you will end up with even worse symptoms, like thinning hair, a higher voice, your balls will become smaller and shrivel up and your penis will become smaller.  Coming down with Peyronie's may be a huge Wake-Up call, to make those necessary changes in your lifestyle.    
Testosterone production in the body is at its' maximum during late adolescence and early adulthood.  After age 30, the body starts tapering off testosterone production by around 1% per year.  Sometime in our mid to late 30's almost all men experience a change that we chalk up to a reduction of our metabolism.  Suddenly you can't just eat whatever you like and not gain weight.  You may notice reduced vitality and energy, that you had in  your early adult years.  There is an epidemic of low testosterone in men over the age of 40 in society today.  Many of the causes can be chalked up to environmental hazards.
The produce you buy at the grocery store is drenched with pesticides.  Many crops are treated multiple times before reaching market.  The top dirty dozen produce offenders are: 
  1.  Apples; remember the old adage, an apple a day keeps the doctor away.  Well apples are treated multiple times with different types of pesticides before they go into your mouth. 
  2. Celery
  3. Strawberries 
  4. Peaches
  5. Spinach, that dark green leafy vegetable that made Popeye so strong.  
  6. Imported Nectarines 
  7. imported Grapes
  8. Sweet Bell Peppers
  9. Potatoes
  10. Blueberries, the berry that is touted for all of its' antioxidant qualities. 
  11. Lettuce 
  12. Kale and Collard Greens, who would have known?
    Pesticides are one of the main culprits for producing the  hormones that mimic estrogen in the male body.

Estrogen wipes out the benefits of Testosterone, so the manly thing to do is eat organic produce.  OK there are those guys that have an almost exclusive diet of meat.  Surely those guys are safe from Estrogen?  Think about it . . . what do those animals eat?  Feed that has been treated with pesticides, growth hormones, and antibiotics, so you still get your estrogen, along with more than you bargained for.  Just like breathing 2nd hand smoke.  You have to go back to free range organic chicken, grass fed beef and maybe hunt wild animals to get healthy meat.  Fish should be harvested wild, from cold water, and not be farm raised like much of the Atlantic Salmon.
Plastics are next, they contain phthalates that also mimic the female hormone estrogen.  It is impossible to get away from plastics in our society.  The water you drink comes in a plastic bottle.  The water going to your home comes in a plastic pipe.  Almost every food you purchase comes wrapped in plastic.  Canned foods are no better.  The inside of cans are coated with BPA, which has an estrogenic hormone affect on those that eat the food.  Bisphenol A (BPA) leaches into the food when heated.  Most all canned foods are filled with hot food during the canning process.  These phthalates attack your bodies ability to produce testosterone.

Soy and Soy Milk have been promoted as the healthy answer for milk and meat replacement.  It began with Tofu eating Hippies in the late 60's, and has grown into a huge industry.  There is a big problem with Soy.  It contains phyto-estrogens that have proven harmful to men's ability to produce testosterone.  These estrogenic compounds cannot be removed by boiling or cooking.  Fermenting Soy to make Tofu, does not remove these compounds. Soy protein powder should not be taken.  Many other vegetables and peanuts, contain these hormone compounds, but they are reduced or eliminated through cooking.  Soy can be eaten in Miso, Tempeh and in Natto, where bacterial enzymes break down the saponin enzymes which then are effective in reducing cholesterol in the blood.   

We are seeing the feminizing of men at an unprecedented rate in today's technological world.  It's time to fight back.  Don't lose your masculinity.

Low T Therapy or Testosterone replacement therapy should not be undertaken to correct this problem.  
It can leave you worse off, than before it began.  Testosterone replacement in the form of pills, creams and patches will boost your T levels, but your body will shut down its' own natural process of producing free testosterone and  your testicles will begin to atrophy (shrivel up).  The best way to improve Testosterone production is to use natural ways to increase production.

So Let's Get Started!    

First off, We begin with Diet!  That doesn't just mean changing the food you eat, it also means going on a diet to lose that belly fat.  Excess fat absorbs almost all of the Testosterone your body produces and then stores it, where it is useless.  So begin by limiting caloric intake immediately.  Just stop putting so much food on that plate.  Practice pushing away from the table.  OK . .  enough said, just practice portion control.

Next we change the kinds of food we eat.   
Go into warrior mode and think, "Sugar and Carbs are my Enemies!" 
 Start by only purchasing and eating organic produce.  Yeah, I know it is more expensive, but the cost of major medical care down the road will offset the extra expense now.  Maybe you can eat more backyard produced fruit, or plant some trees and grow a garden.  The best way to eat healthy is be sure about where and how your food is grown and harvested.

This is a really good time to stop smoking.  Smoking lowers Nitric Oxide, which is your erections best friend.  The damaging effects of smoking are slow and cumulative.   They build up over time.  Smoking will lead to a bedroom train wreck that is dose and time related. The more time you smoke and the more packs of cigarettes you smoke add up to sustained erectile dysfunction, but the process is reversible if you stop smoking now.

Remember the Marlboro man? He died of lung cancer.  My wife and I lost a good friend to lung cancer, and believe me, it is not a pleasant way to go. I still have vivid memories of listening to Pat cough and gasp, trying to catch another breath.

Next we move on to the part I really despise.  This is something many of us avoid and that is physical exercise.  Why is it so hard to get into a exercise program?  Well because it Hurts!  That's why!  The kind of exercise that boosts Testosterone isn't just going for a walk or a short jog.  If you really want to boost you testosterone levels, you need to lift heavy weights. 
Hit the weights hard: Consistent, heavy weight lifting helps the body build muscle and produce testosterone.  Don't spend your time on the treadmill, lift weights and work on the bench press. Packing on muscle and bulking up, increases testosterone production.
Hurts So Good - Strength Training increases Testosterone

After Diet and Lifestyle changes we also can boost Testosterone production with supplements.  This one will use the
  1. Green Light,(Take this one) Science and Medical studies back up the effectiveness of this supplement.
  2. Yellow Light (Caution, the Jury is still out on this one)
  3.  Red Light (No clinical evidence that it does anything)

  • Zinc: A study was done with two groups of men, one group had low testosterone and the second group had normal levels.  The low T group had an increase in testosterone and sperm count with oral administration of zinc.  The group with normal levels did not show an increase.  The indication of the study is, Zinc will raise low levels of testosterone to normal, but not above that level.  Doctors have seen a correlation between low zinc levels and low testosterone levels for decades now.  Zinc is a definite one to take.  Dosage Guideline: Patients in the study took 30 mg zinc monomethionine aspartate daily.  Taking too much zinc can cause nausea, upset stomach, and vomiting.  It is not recommended to ingest more than 40 mg. daily.  Taking more than 100 mg. daily for ten years or more doubles the risk of prostate cancer.
  • Avena Sativa:  Oat grass or Wild Oats may free up testosterone that gets stuck in various compounds in the body.  The  link of Avena Sativa to Testosterone may be hearsay.  I was not able to find any scientific studies to back up its' use.  The juries out on this one.
  • Nepal Yam: or Discorea Deltoidea is said to boost hormone levels from the pituitary gland.  The rise in luteinizing hormones may or may not help raise testosterone levels.  There is the possibility that yam may raise estrogen levels.  The problem with Yam is, steroids can be manufactured from them (both Testosterone and Estrogen).  You do not receive any hormone benefit by ingesting yams or yam extract directly.
  • Vitamin D: Go outside and catch some rays, this is the best and most natural way to get a healthy dose of Vitamin D. Americans have a chronic Vit. D deficiency, due to lifestyle.  Most of us spend too much time indoors. Vitamin D stimulate the release of free testosterone, which improves sex drive, reduces fatigue and improves well being.  If you cannot get enough sun exposure due to work, climate or other reasons, then taking a well-made supplement is essential.  Dosage Guideline: Expose a large portion of your skin to sunlight until it turns the very lightest shade of pink.  Do this as close to solar noon as possible to get the maximum dose in the shortest time.
  • Tongkat Ali: I'm going to spend a little extra time on this one, because it has shown a lot of promise in medical studies and is endorsed by many medical doctors.  Tongkat Ali reduces cortisol levels and increases free testosterone levels in numerous medical studies. 
    Tongkat Ali is a rare herb found only in the lush virgin tropical rainforest of Indonesia and Malaysia. You can easily raise your testosterone level to youthful level and enjoy these benefits.
  • A high sex drive and libido
  • Longer, harder and more spontaneous erection
  • Improve muscle mass and strength 
  • A boost in energy and vitality
  • Increase bone mineral density
  • A sense of well being
  • Improve cognitive function

How do purchase the right Tongkat Ali?  After all, not all manufacturer's produce a high quality and pure product.  There are several things that you should not compromise, when buying Tongkat Ali.

  1. Tongkat Ali root extract is effective, the leaves and stems are not beneficial.  So buy Tonkat Ali root extract - not Tongkat Ali powder.
  2. Extract Strength is important 100 to 1 or 200 to 1 is best.  Some are only 5 to 1 or 10 to 1 and will not work, they are too low. Extract strength means that 200 grams of root were used to make 1 gram of extract.
  3. Tongkat Ali extract only is the best product.  Do not buy Tongkat Ali powder, as the strength is 1 to 1 with ground up root powder.  You would have to ingest too much to get the same results as extract, which has been concentrated. Extract gives you concentrations of 100 to 1 or 200 to 1.
  4. Buy Indonesian Tongkat Ali, Chinese Tongkat Ali has a high level of heavy metals and there is no guarantee that the roots are even Tongkat Ali, or some other plant. Some argue that Indonesian Tongkat Ali, is the best, others say there is no difference between Indonesian and Malaysian.  Indonesia is the only place where Tongkat Ali grows wild.
  5. Tongkat Ali Roots
  6. Roots that are from old plants are the best.  10 years minimum make the best extract.  Older roots have more active ingredients and increase the extract strength and effectiveness.
I have done a lot of research into brands of Tongkat Ali and finally found one that meets all of the criteria above. You can click on the link below to purchase it there.

Dosage Guideline:

The recommended usage is 4 capsules per day: 2 in the morning and 2 in the afternoon. However, this may be a little too high for some users, specially if this is the first time you start taking the product. I recommend starting with half the dosage until you feel that your body is OK with it (that is, you don’t feel agitated or restless). Then you may increase to the standard 4 capsules per day.

I suggest that you experiment a little with the dosage as Tongkat Ali doesn’t work the same for all individuals (neither does any other supplement or medication). You may notice that you experience the desired effects taking only 2 or 3 capsules per day, and that is totally fine, stick to it. Some other individuals (specially bodybuilders) may find a higher dosage more suited for the results they look for.

The effects of Tongkat Ali accumulate gradually. However, it is also important to leave a “resting period” to avoid your body getting accustomed to Tongkat Ali. It is recommended to rest half the time you take Tongkat Ali. For example: If you take it for 4 days in a row, rest 2. Or if you take it for 2 days, rest on the third, then take it for another 2, then rest on the third, etc.
If you are taking Tongkat Ali long term, I believe it is a good idea to let your body rest for a longer period after 2-3 months of cycles (you can take a one month break or so).
  • Fenugreek:  Fenugreek seeds are super popular for increasing testosterone, but they also are believed to block DHT (dihydrotestosterone) Medical study results were completely inconclusive in showing any change in steroidal hormone levels in test subjects.  They did reduce fertility in animal studies on both sexes of rabbits. Taking Fenugreek to increase Testosterone is a bad idea, even though it is highly touted by some supplement manufacturers.  Fenugreek is effective in reducing blood glucose levels in one study.
  • Creatine:  Creatine is cheap and effective.  This is borne out in more than 70 peer reviewed human studies. Studies show that Creatine improves physical power output, improves cellular hydration and induces lean body mass, while decreasing fatigue.  Creatine increases DHT levels which in too high levels can cause male pattern baldness and prostate enlargement.  So Creatine should not be taken in large doses.  Competitive weight lifters commonly take  more than 5 grams daily.  Dosage Guideline: 3 grams daily for a month, then take 2 weeks off completely - Repeat  CAUTION: Creatine increases cellular hydration, so you are using water more efficiently while supplementing.  Make sure and drink plenty of water to avoid dehydration or water retention.  Too much Creatine is hard on the kidneys, just like too much food makes you fat and too many vitamins are toxic. Don't overload on Creatine, remember too much of a good thing turns into a negative.
  • Green Tea:  Green tea is found in some Testosterone supplements, and it is healthy to drink a glass of green tea from time to time.  There is no evidence for Green tea helping to boost testosterone, in fact, chronic use of Green tea resulted in higher levels of aromatase in rats, which raises levels of estrogen and lower levels of testosterone.  Consuming green tea for its' anti- inflammatory qualities is healthy, but chronic use, should be avoided.  Tea tree oil should be avoided, as it is concentrated and has been found to introduce phyto-estrogens into the body.
  • Coffee/Caffeine: Caffeine gives you that energy kick in the morning and enhances mental clarity.  Coffee also helps to control appetite.  Caffeine is found in some Testosterone supplements.  Its' effect on Testosterone in men is minimal, there was a very a slight increase, with moderate use.  Women were found to have a slight reduction in testosterone production with caffeine.  Dosage Guildelines: 3 cups of coffee a day amounts to around 250 mg. of caffeine and seems to be a healthy level of consumption.
  • Horny Goat Weed: Well this one has been extensively studied on rats and humans.  The name comes from sheep and goat that became quite amorous after eating the plant. (Epimedium)  Rats developed healthier genitals and had higher levels of testosterone and it had an anti-depressant effect on the rats in the studies. 

Heat Treatment for Peyronie's

Lately I have been receiving quite a few questions in emails about heat treatment for Peyronie's.  It is time to explore it's effectiveness and how to safely do it.

First off, we all know how tender and sensitive the penis is, and heat treatment must be done carefully, to avoid burns or injury.  Heat does lower sperm count temporarily and never apply anything over over 111 degrees Fahrenheit or 44 degrees Celsius, over extended periods of time, to avoid scalding.  

Next let's look at the results of heat treatment.  A small pilot study was performed, using a specially designed Andro-thermic heating device.

Heat was applied for 20 minutes, twice a week for 5 weeks.  A second cycle was done after 1 month of 10 treatments.  The control group, for comparison received Verapamil injections and no heat treatment.

The Heat treatment group saw a 55.9% reduction in curvature, compared to 3.8% in the Verapamil group.  Plaque reduction was similar in percentage value.  The photos shown in the report are something you should see.  The extreme curvature reduction is impressive.  Click on the link below to view the report.  Scroll down to page 8, if you just want to see the photographic results.

 The method I used when treating myself, was to put my hand in running hot water to test the temperature.  It was probably between 105 - 108 degrees.  You have to use common sense and good judgement to avoid burning your self.  I then ran the water on a hand towel and wrapped it around my penis.  I had to warm up the hand towel 2 - 3 times to achieve about 10 minutes of heat treatment.  You could use a hot water bottle, or small hand warmer with a moist hot cloth around it, to avoid having to re-heat the cloth, to achieve a sustained 10 minute time.

My method was simple and not very scientific, but my wife and I were very happy with the final results.  

An earlier study found that heat applied to collagen caused the collagen cells to become 'floppy.' The researcher used this term, for lack of a more scientific word.  I would apply the DMSO/SSKI topical compound immediately after the heat treatment session.  My idea was to attack the plaque, while it was in a 'vulnerable/floppy' state.  Heat increases circulation locally and softens the collagen in the plaque.  My reasoning was to use multiple protocols to destroy this enemy.

Insulin Resistance and Peyronie's

In my short book, on page 20, I made a statement about causes of Peyronie's, and the higher incidence occurring in men with insulin resistance. Since that time I have not elaborated on this issue, so it is time to look into this issue a little deeper.

Detailed Description and Insulin Resistance Bood Testing:  
It is well known that diabetes often leads to erectile dysfunction. Because insulin resistance occurs before diabetes, it is possible that erectile dysfunction may occur in some individuals while they have insulin resistance, but before they develop diabetes. If this is true, it might be possible to use erectile dysfunction as a sign of insulin resistance, which may lead to more timely treatment of insulin resistance and may delay or prevent the development of diabetes, and the other problems mentioned above.
Insulin is a hormone produced by the body that lets sugar into the cells, where it is used for energy. Insulin resistance occurs when the body’s cells have a decreased ability to react to insulin. This leads to an increase in insulin secretion. Over time, insulin resistance can lead to higher levels of sugar in the blood (diabetes), and can also contribute to obesity, high blood pressure, high cholesterol levels and heart disease. There are no simple tests to actually diagnose insulin resistance. Currently, the glucose tolerance test is used to diagnose IR, but it involves several blood draws over a 2-hour period. Another purpose of this study is to compare a blood test involving only one blood draw to the 2-hour glucose tolerance test, which involves several blood draws over a 2-hour period.

There is a very well thought out forum post about Insulin resistance, and Diabetes and their relationship to Dupuytrens, which has a very similar etiology to Peyronie's.  Many men develop both of these conditions simultaneously, since they may be predisposed genetically.
The post is well worth reading and gives some great dietary advice.  You can read it by going to this website:

The post was written in 2005, but I just came across it,  it has some very good advice and valuable information about insulin resistance, diabetes and the way proteins may accumulate and build up.

Natural Alternatives for Treating Erectile Dysfunction

Viagra Alternatives and Penis Enhancement Pills

Sildenafil Citrate, Taldenafil, and Vardenafil are all prescription brands for treating erectile dysfunction.  They are classed in a group of drugs that are PDE5 inhibitors.  To read more about how they work, side effects, and safety, click on this link:  

 What is Viagra and Generic Viagra

For men suffering with erectile dysfunction, it can be be very distressing.  Many men do not want to take a prescription drug for this problem or add another drug to those they are already taking.  It has been shown through surveys, and clinical studies, that the more prescription drugs a man takes, the more likely he is to suffer with erectile dysfunction.  Consumer Reports on causes of ED

There are a host of supplements out there that make some pretty wild claims like; 

Works in less than one hour,  Add up to 4 inches in length to your penis.

I haven't heard of any documented cases of men taking a pill and their penis magically growing longer, but it doesn't keep men from spending loads of money and the scammers from taking advantage.  

Remember the Smiling Bob Enzyte commercials?  Well in 2005 the CEO of Enzyte went to prison for fraud.  Still many men still swear by Enzyte and its' effectiveness for treating erectile dysfunction.

Let's take a look at some of these "Miracle Penis Pills ."
Enzyte, VigRX, Zyrexin, Longinexx, Extenze, Penatropin, and Magna RX, all have something in common.  That ingredient is L-Arginine.

L -Arginine:  
L-Arginine is an amino acid that is responsible for increasing Nitric Oxide in the blood.  It is not always well absorbed by the body, so it is most effective when taken along with Nitric Oxide precursers, such as Pychnogenol or L-Citrulline.  Nitric Oxide relaxes the veins of the penis, allowing increased blood flow, which is critical for erection.

Saw Palmetto:  
Saw Palmetto is also a common ingredient that is a part of most of these pills.  The fruits of    the saw palmetto are highly enriched with fatty acids and, beta phytosterols and extracts of the fruits have been subjected to loads of research for the treatment of prostate enlargement symptoms. Saw Palmetto is widely used and recommended for Prostate health.  Its' effect on erection quality is unknown.

Tribulus Terristris:

Commonly known as puncture vine extract, which many of us may be painfully aware(ouch) if you ever stepped on them with bare feet.  Tribulus Terristris is found in some of the pills.  Animal studies in rats, and primates have demonstrated a mixed bag. One study found that Tribulus terrestris extract can produce statistically significant increases in levels of testosterone, dihydrotestosterone and dehydroepiandrosterone, and also there was an effect that suggested aphrodisiac activity.


On the other hand, one recent study found that T. terrestris caused no increase in testosterone or LH in young men

Butea Superba:
This ingredient is in Longinexx and Penatropin.  These two pills are marketed as enhancement pills and Butea Superba is a herb from Thailand that is thought to be an aphrodisiac.  There are no double blind clinical studies to support this aphrodisiac effect, but many men claim it works.  Ingesting large amounts 10-16 grams a day resulted in decreased testosterone levels, probably due to the phyto-estrogens found in the herb, which some believe can cause men to grow larger breasts .

DHEA (Dehydroepiandrosterone) is a hormone/steroid that is made by the human body. It can also be made in the laboratory from chemicals found in wild yam and soy. However, the human body can't make DHEA from these foods, so simply eating wild yam or soy does not increase DHEA levels. Don’t purchase wild yam and soy products labeled as “natural DHEA”  it won't be effective in raising your levels.

DHEA is used by men for erectile dysfunction (ED), and by women  who have low levels of certain hormones to improve well-being and sexuality.

DHEA is Probably Safe for most people when used for just a few months in doses that do not exceed 50-100 mg. daily. It can cause some side effects which include acne, hair loss, stomach upset, and high blood pressure. Some women  have noticed changes in menstrual cycle, facial hair growth, and a deeper voice after taking DHEA

 The best selling natural Viagra alternative is Zyrexin.  You can even buy it at Walmart, which  has one of the lowest prices for this product.  
If you really want to make a difference, lose some weight, it will make your penis look longer, because you reduce the fat that surrounds and conceals your natural length.  To increase erectile quality lose weight and stop smoking.  Smoking is a leading cause of vascular disease and smokers are twice as likely to develop ED than non-smokers.  

Doctors for the most part do not think that penis enhancement pills work.  Those that do are less than enthusiastic, gains are almost always temporary from taking enhancement pills.  The most noticeable gains are achieved from enhanced erections, which temporarily lengthen the penis.

The best natural supplements for increasing erections quality should contain L-Arginine and a percurser like pychnogenol or L-Citrulline.  Many men are happy with the results of Zyrexin and it is readily available.  You can try DHEA for a short duration to increase testosterone and boost your libido and sex drive.  If these options do not work out, then consult with your doctor for other available options.  

When purchasing supplements beware of SCAMS.  Buy your products from reputable sources, like the Vitamin Shoppe, Amazon, Walmart, GNC, etc.  Avoid getting roped into "Free Trials" or "Autoship" products.  They can get very expensive, very quickly. 

If you go to 10 different websites promoting penis enhancement pills, you will get 10 different opinions on a multitude of products.  Much of the information is conflicting, so be careful and do your research before parting with your hard earned money.

L-Arginine how does it work for Peyronie's

L-Arginine keeps coming up as a treatment supplement for Peyronie's

I see L-Arginine being recommended for Peyronie's a lot lately.  What is the story, and why is it getting so much attention?
L-Arginine has been tested in clinical studies, and it has been found to be very effective for treating erectile dysfunction.  In one study after 3 months of combination therapy using pychnogenol and L-arginine, 92.5% of the patients acheived normal erections, which is a significant and amazing statistic.

What is it that L-arginine and Viagra have in common?  Nitric oxide (N.O.) is the answer.   N.O. is essential for a penile erection.  It works by sending a message to the smooth muscles of the corpus cavernosum (erection chambers in the penis) to relax.  When the muscles relax blood flows into the corpus cavernosum, causing the penis to become erect.  The idea of supplementing with L-arginine for Peyronie's is not to directly remove the plaque, but to allow increased blood flow to the penis.  The increased blood flow is thought to aid in the healing process.

Many doctors and urologists recommend L-arginine supplements for conditions from Peyronie's, Erectile dysfunction, to regulate blood pressure, reduce inflammation, cardiovascular health, and improve sleep quality.  It also is thought to increase endurance and strength. 

So there is a lot of information supporting the use of L-arginine in the treatment of Peyronie's.  The next question is:  "What is the best form of L-Arginine to take?"

L-Arginine when taken in large doses was shown to increase Nitric Oxide in the blood and urine.  One of the problems with L-Arginine supplements, is the amino acid is not readily assimilated and absorbed by the body.  It is better to take a combination product, where more of the L-Arginine is absorbed.  L-Citruline is better absorbed and converts into L-Arginine in the kidneys.

I recently purchased a bottle of Source Naturals, L-Arginine, L-Citrulline Complex from the Vitamin Shoppe.  It contains 750 mg. L-Arginine and 250 mg. L-Citrullene.  Suggested Use is 1 tablet 3 or 4 times daily.  The bottle contains 120 tablets. 

L-Citrulline is a amino acid found in some foods like watermelon, and it is produced naturally in the body.

L-Citrulline is used for treating Dementia/Alzheimer's, muscle weakness, erectile dysfunction, high blood pressure and is used by body builders for increasing energy and improving performance.

Your body changes L-Citrulline into L-Arginine and also to Nitric Oxide, so it is a perfect companion to an L-Arginine supplement.  It is believed to increase and improve blood flow and reduce blood pressure.

If you are suffering from Peyronie's, ED, or just feeling run down and want to increase your performance level, then you might want to consider taking this supplement.  Click on the Vitamin Shoppe tab in the right hand column to go to their website and order your own bottle.  L-Arginine was found to be effective in raising Nitric Oxide levels and improving sexual performance and erectile quality in many medical studies. 


Non Invasive Treatment Studies for Peyronie's

  Non Surgical Peyronie's Studies

I will start this article about Medical studies with Drugs and Supplements that have been studied and the results, and also cover some other products that have not been tested.  If you wish to take the time to go through these studies, you will see the reasoning behind the 3 step program that I developed and used to successfully treat my Peyronie’s disease.
Colchicine is a drug that is mainly used to treat Gout due to its’ anti-inflammatory qualities.  It is also known to reduce the production of collagen and increase the activity of collagenase. (the enzyme that breaks down collagen)  Colchicine is extracted from the “Meadow Saffron” plant.  It is a toxic drug and its’ toxic qualities are amplified or multiplied when combined with cholesterol lowering drugs. (statins)
Adverse Reactions to Colchicine include nerve damage that causes numbness and tingling in the hands and feet, in advanced cases this effect can be permanent along with an increased risk of dementia.  Large doses can result in respiratory failure and death.  Colchicine is not FDA approved for treating Peyronie’s Disease and the toxic side effects really are not worth the risk, since study results have been mixed.
An uncontrolled group study of 24 men took Colchicine in 1994.  The results of the study were, 26% of the men reported a marked decrease in curvature, 11% reported a slight decrease, 63% were unchanged, and 50% of the men reported plaque size reduction.  I do not have the duration or dosage taken in this study.
The next study in 2004, involved 78 men broken into two groups.  One group took .5mg-2.5mg. colchicine per day for 4 months.  The other group took a placebo.  There was no difference in curvature reduction reported between both groups.  There was another study undertaken using 84 men with the same protocol above.  All of the men were screened to make sure they had similar duration of disease – 15 months.  The results were no difference between Colchicine group and placebo group.
Pentoxifiylline works by changing the shape of red blood cells in the body, thus reducing the viscosity (thickness) of the blood.  This allows blood to circulate more freely, especially to the bodies extremities.  Pentoxifylline acts as a mild stimulant and is in the same family as caffeine.  Men that are allergic to caffeine should not take Pentoxifyllline without medical observation.  Brand names are Pentoxil and Trental.
A study by the University of California at San Francisco treated 71 men with Peyronie’s Disease.  62 men took Pentoxiffyline for a year and 9 men received no treatment.  The calcifications stabilized or improved in 57 of the 62 men who took Pentoxiffyline compared to 4 of the 9 men in the no treatment group.  I found no reports of curvature improvement in the study, so that part is unknown.
Another larger study with 228 men participating was don at Ahahid Beheshti University in Tehran, Iran.  114 men took 400 mg. Pentoxifylline twice daily.  The other 114 men took a similar regimen of placebo.
Results: 35.9% of the men in the PTX group reported a positive response with only 4.5% in the placebo group.  Improvement in measured curvature on average was between 11.4 – 11.7% in the PTX group.  In the placebo group curvature improvement was .2 to neg.4.2%
11% of the PTX group still have disease progression compared to 42% in the placebo group.
In a study using Tamoxifen VS. Placebo there was no significant improvement VS. the placebo group so this study is a non-story.
Tamoxifen VS. Acetyl-L-Carnitine:
Results: Acetyl-L-Carnitine was significantly more effected and safer to use in the treatment of early acute Peyronie’s Disease.  Tamoxifen induced significant undesirable side effects.
The body produces carnitine in the liver and kidnesy and then stores it in the heart, brain, sperm and muscles.  It acts as an anti-oxidant and helps restore cells damaged by inflammation.  Only one study has been done on L-Carnitine for treatment in Peyronie’s Disease.  Acetyl-L-Carnitine significantly reduced penile curvature and plaque size. (Biagiotti, 2001, Turin, Italy)
The suggested dosage of carnitine for Peyronie’s Disease is 1 gram (1000 mg.) twice daily for three months.
L-Arginine is a popular supplement for Peyronie’s but studies are very limited.  In 2003 a study found arginine given to rats in mixed in their water.  L-Arginine was effective in reducing plaque building components. L- Arginine was also used in an another study, but it was combined with other drugs, so the reports would be mixed and not statistically significant.  There are other studies with L-Arginine in treatment of erectile dysfunction and the results are significant.  I will be posting a separate article on L-Arginine soon.
L-Arginine should not be taken with sildenafil (Viagra), or with blood pressure lowering medications.
PABA: Para-Aminobenzoic Acid
PABA (Para-Aminobenzoic Acid) is a popular Peyronies remedy. It is best known as a sunscreen in topical lotions, since it blocks UV light.  The reviews are mixed on how effective PABA is for treating Peyronie’s. A typical safe dose of PABA for therapeutic use is 400 mg. daily. Most of the studies using PABA are very old, dating back to the early 1940′s.
There is only one double blind placebo study that I could find, that used a control group of over 100 men with Peyronies. The trial enrolled 103 men and for one year they ingested 3 grams, 4 times daily. The progression of their Peyronie’s was significantly slowed, but it did not reduce any pre-existing plaque. Doctor’s consider 400 mg. a day a safe dose, but the men in this study were ingesting 12,000mg. or 12 grams daily. This is far beyond the safety threshold, and should not be done except under strict medical supervision.
In 1959 a study was undertaken with 21 patients and another study in 1997 included 32 patients, but since they were not double blind placebo studies there was not a control group to compare the results with. These studies used from 12 grams daily to a maximum of 20 grams daily. Because it takes such high doses of PABA to get a positive response, and it causes significant gastrointestinal side effects, PABA for Peyronie’s Disease often is not recommended as a treatment. Other more uncommon side effects include nausea, reduced appetite, fever, and rash. PABA can also interact with some medications, including sulfa antibiotics.
Vitamin E
Vitamin E as an oral supplement has been extensively studied, and shown to have no impact on Peyronie’s Disease.  Vitamin E may be effective in combination with other supplements and treatment combinations.  One possible medical regimen is 100 mg of vitamin E taken three times a day for a minimum of four months. Theoretically, this antioxidant will prevent further development of plaque, although studies have suggested that it is no more effective than placebo.
Gotu Kola 
Use of Gotu Kola, which is also called Centella asiatica, Indian pennywort, and other less known names is believed to contain certain chemicals that seem to decrease inflammation and also decrease blood pressure in veins.  Gotu Kola is used to treat various conditions in which fibrous scar tissue causes problems, and for that reason it has been advocated for Peyronie’s disease. However,  there are no studies with evidence to show that it is effective.  http://www.med.nyu.edu/content?ChunkIID=35551
Some of the comments about Gotu Kola at the Peyronies’ forum can be read  here: http://www.peyroniesforum.net/index.php?topic=2940.0
The verdict is out on Gotu Kola’s effectiveness in treating Peyronie’s, but it does seem to have many other health benefits, and is generally accepted as safe.
Omega 3 Oils
The data from a study of 224 patients with chronic Peyronie’s Disease was divided into two groups.  The results of the study did not show any data that would support Omega 3 supplements to be beneficial in treating chronic Peyronie’s Disease.
One of the problems with this study in my opinion, was the low dosage of Omega3 that was given to patients, and the questionable quality of the products administered.  There are all types of Omega3 oils, and many brands are so processed, that their effectiveness is in doubt, and questionable at best.

Proteolytic Enzymes
Serrapeptase is a potent proteolytic enzyme that contains 470 amino acids and a zinc atom, which is essential for proteolytic activity.  Medical studies have not been done for treatment on Peyronie’s Disease specifically, but other medical studies have proven this enzyme to be more effective in anti-inflammatory activity on collagen than the other proteolytic enzymes that were used in the study.  It was also shown to have a synergistic effect with aspirin.  (2008 Dept. of Pharmacology, J.N. Medical College, India)
A study conducted in Jordan in 2008,  found Serrapeptase to offer significant reduction in swelling and pain, with oral surgery, and no negative side effects.  It has been used in numerous studies from Breast engorgement to acute inflammation in chronic ear, nose and throat disorders, with significant symptom reduction.  These double blind placebo studies found that Serrapeptase was well tolerated and its’ anti-inflammatory, anti-oedemic and fribrinolytic activity, acts rapidly on localized inflammation.
Serrapeptase/Nattokinase blends have been found to be very effective in the reduction of Fibroid tumors, and Endomitriosis in women.  Serrapeptase also has the ability to digest non-living tissue that is a by-product of the healing response without harming living tissue. Serrapeptase is used to dissolve non-living tissues to include: scar tissue, fibrosis, blood clots, cysts and arterial plaque. It is also used as an anti-inflammatory agent against Sinusitis, and as a thinner for mucous secretion.
Bromelain is a powerful proteolytic enzyme that has anti-inflammatory effects and is known to increase fibrinolytic activity in the blood.  Bromelain is derived from pineapples. Bromelain is a popular enzyme used in the treatment of Peyronie’s Disease.  It is a candidate for studies, because of its’ link to promoting the enzyme collagenase, which digests collagen.  Bromelain has many of the qualities of Serrapeptase but it is not as well tolerated.  Common side effects include diarrhea, increased heart rate, nausea, stomach pain and vomiting.  Avoid Bromelain if you are allergic to bee venom, carrots, celery, papaya, pineapple, rye, wheat and pollen.
Bromelain by itself is effective as a blood thinner.  When taken with blood thinners it can raise the risk of bleeding.  Bromelain for health maintenance is generally deemed safe at 50 mg. a day with little risk of side effects.  The recommended dose for treating Peyronie’s is 500 mg. a day.  This high of a dose should not be maintained on a long term basis.
Topical Gel Applications
DMSO with Serrapeptase was studied in use for a transdermal topical gel to treat subcutaneous inflammation.  It was found that DMSO concentrations had to be  unacceptably high in order to transfer the enzyme beneath the skin, due to Serrapeptase having a large molecule weight, it would not readily permeate the skin.  Indian J Pharm Sci. 2010 Jan-Feb
DMSO with iodine was found to reduce infections and increase the effectiveness of iodine alone in hospitals where Staphylococcus epidermidis was causing increased infection, mortality, and health care cost. (J Clin Microbiol. 2012 May)
An article by Dr. Jonathan Wright of the Tahoma Medical Clinic discusses the use of Iodine and DMSO  http://tahomaclinicblog.com/iodide/
DMSO may be an important stimulator of the tumor suppressor protein HLJ1 through AP-1 activation in highly invasive lung adenocarcinoma cells. Targeted induction of HLJ1 represents a promising approach for cancer therapy, which also implied that DMSO may serve as a potential lead compound or coordinated ligand for the development of novel anticancer drugs. (Published online 2012 April 17)
DMSO in the treatment of Scleroderma.  Scleroderma is a baffling disease in which the body begins manufacturing collagen, where it begins collecting in the extremities.  Scleroderma often will go into remission, but can be fatal if it continues its’ progression, unabated.  Dr. Jacobs is well known for treating Scleroderma with DMSO.  The following is the conclusion of this study.
The relief of pain, stiffness and, to a lesser extent, weakness in these patients who have been treated with DMSO is impressive, and most of the patients are continuing maintenance treatment. It appears that DMSO, as administered at present, has no effect on the internal manifestations of scleroderma. Of 26 patients who had good to excellent improvement, 16 had minimal, and eight had moderate disease, according to our criteria for classification of the severity.
It should be emphasized, however, that the results seen in treating patients with scleroderma with DMSO have never been observed with any other method of therapy. It is the first time we have observed evidence, both clinical and histological, that the collagen is undergoing definite change.
Verapamil GEL has been falling from favor as a viable treatment option of Peyronie’s.  A survey of 236 practicing urologists in 2008 found that only 10% selected Verapamil gel as their first treatment choice.  In 2002 Loyola University Medical center came to the conclusion in their study that the use of transdermal verapamil has no scientific basis.  Transdermal Verapamil does not infiltrate into the Tunica Albuginea.  Wish I had known this before spending $1,000.00 on Verapamil.
 Intralesional Injection and Iontophorisis
Verapamil VS. Saline – Iontophorisis, electromotive drug administration.  This placebo study has 23 men in the Verapamil group and 19 men in the saline placebo group.  Results:  The Verapamil group achieved greater decrease in curvature, but the results were not statistically significant.  The results concluded this option was effective in patients complaining of pain and with mild curvature.
Verapamil Intralesional injection, (Long term study 1994-1996 Dept. of Urology, Montefiore Medical Center, Bronx, NY)  Conclusions:  The study suggests that intralesional injection may be a reasonable approach in some selected patients with non calcified plaques and penile angulation of less than 30 degrees.
A placebo controlled study involving 80 patients in Iran, actually showed more curvature decrease in the saline control group, than in the Verapamil group.
Corticosteriod injections VS. Saline Placebo:  Placebo was more effective in curvature correction than the cortisol group . . . enough said?
Another reason that steroid injection has become less popular is that we know that steroids can result in tissue atrophy, and thereby may cause thinning and weakening of the penile tissues. Therefore, with rare exceptions the use of intralesional steroids have been completely abandoned.   http://www.peyroniesassociation.org/forums/topic/intralesional-injection-therapy-dr-laurence-levine/

Interferon Alpha 2B injections VS. Saline Placebo: A study of 39 men at Tulane University, New Orleans, LA,  injected Interferon Alpha 2B directly into the plaque of 19 men.  20 men received saline placebo injections.  Same protocol for each group, injections were given once a week for 12 weeks.  6 months later they received a follow up visit and evaluation.  The Interferon group showed significant improvement over the placebo group in curvature, plaque size and density, and pain with erection.
30 men in Ankara Turkey were studied using a similar protocol as the test above for management of early stage Peyronie’s.  The conclusion was that Interferon Alpha 2B was not clinically effective in treatment and management of early stage disease.
Interferon Alpha 2 B frequent side effects are fever, and mild to moderate flu like symptoms,of short duration.  Further study is currently ongoing to determine precise quantities and frequency of application to be most effective.
Xiaflex by Auxilium Pharmaceuticals  clinical studies for FDA approval have shown impressive results with intralesional injections of Xiaflex.  Phase III studies showed 67% of patients showed significant improvement.  Significant improvement was counted as a 25% improvement or better from the original measured angle. http://www.auxilium.com/productpipeline/PeyroniesDisease.aspx

Combination Therapy:


Department of Urology, Rush University Medical Center, Chicago, IL 60612, USA.


Non-surgical treatment of Peyronie’s disease (PD) has come a long way since it was first described in 1743. A myriad of treatment options are currently available, including oral, intralesional and external energy therapies. The purpose of this article is to review the contemporary literature on non-surgical therapies for PD, and where possible, focus on randomized, placebo-controlled trials, as well as review the latest guidelines for the management of PD from the International Committee on Sexual Medicine, which conveyed its findings in July 2009.  At this time, it appears that a combination of oral agents and/or intralesional injection with traction therapy may provide a synergy between the chemical effects of the drugs and the mechanical effects of traction. Until a reliable treatment emerges, it does appear that some of the non-surgical treatments discussed can be used to stabilize the scarring process and may result in some reduction of deformity with improved sexual function.