Peyronie's disease, Erectile Dysfunction, and Sildenafil Citrate

Every man seems to have a different experience with Peyronie's disease.  Some experience pain, while other do not.  Severity of deformation varies widely, with a bend sideways or up or down or bell shaped deformation.  No two men are exactly alike.  Some men experience varying degrees of erectile dysfunction from mild to severe.  Erectile dysfunction is frequently associated with Peyronie's disease.

There is no consensus among patients or doctors on how to treat this.  There has been the belief that Viagra (Sildenafil Citrate) may contribute to PD.  There has not been a proven clinical connection though at this time.  Some doctors will not prescribe Sildenafil Citrate to patients with PD.  The fear is that the potential risk of further injury during intercourse from Sildenafil Citrate is greater than without it.  

Well, if a man has erectile dysfunction, he is probably not going to be performing sexually, without taking something like Sildenafil Citrate.    In some cases the plaque is large enough to block blood flow, resulting in vascular deficiency.  This causes erectile dysfunction beyond the plaque, which can cause hinging at the point of bend.  Hinging can cause penis fatigue, resulting in a fracture, much like fatigue in metal when it is repeatedly folded or bent.  Taking Sildenafil Citrate with this type of ED would increase the danger of further injury or fracture.

The manufacturers of PDE-5 inhibiters, Sildenafil, Vardenafil, Tadalafil (Viagra, Cialis, Levitra), have cautionary notes in  their package, regarding the use of this classification of drugs for men with Peyronie's disease.  The drug manufacturers did not include men with PD in their clinical trials.

73 men with curvatures less than 60 degrees were given sildenafil, as it was assumed that curvatures less than this would not be as susceptible to penetrative injury.  71% of these men were satisfied with their erections and no new pain or deformity increases were recorded in the group.

PDE-5 inhibitors in experimental use were shown to have a
potential anti-fribrotic effect.  When fibroblasts in human Peyronie's disease were exposed to daily low dose PDE-5 inhibitors it resulted in reduced collagen production.  In animal studies; animals were given sildenafil and vardenafil in their drinking water, shortly after they were injected with an agent that triggers  a Peyronie's type scar.  The PDE-5 inhibitors appeared to substantially reduce the development of fibrotic scar tissue in the animal studies. 

Elevated nitric-oxide levels appear to inhibit fibrosis, which forms the plaque.  Sildenafil elevates nitric-oxide levels in the blood and relax the muscles in the penis, which triggers erections when a man is sexually stimulated.

Another good way to boost nitric-oxide is with Arginine and Citruline supplements.  Beets are a rich source of nitric oxide.  A glass of beet juice every day could be the ticket to better cardio health and reduced scar tissue build up.  A good cardio workout will also boost your nitric oxide levels.

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